IDENTIFYING OPPORTUNITIES FOR LATE-STAGE C-H ALKYLATION WITH HIGH-THROUGHPUT EXPERIMENTATION AND IN SILICO REACTION SCREENING

Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening

Abstract Enhancing the properties of advanced drug candidates is aided by the direct incorporation of specific chemical groups, avoiding the rei?llinen pizzalapio need to construct the entire compound from the ground up.Nevertheless, their chemical intricacy often poses challenges in predicting reactivity for C-H activation reactions and planning t

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Historical trends in the epidemiology of candidaemia: analysis of an 11-year period in a tertiary care hospital in Brazil

Candida species are an important cause of bloodstream infections (BSI).To evaluate the epidemiological, clinical and microbiological aspects of two cohorts {1994-1999 [period 1 (P1) ]; 2000-2004 [period 2 (P2) ]} of candidaemic patients, we performed a retrospective analysis from a laboratory-based survey.A total of 388 candidaemias were identified

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Statin-induced bilateral foot drop in a case of hypothyroidism

Muscle involvement is a common manifestation of both clinical motovox scooter parts and subclinical hypothyroidism, with serum creatine kinase (CK) elevation being probably the most common manifestation, and is seen in up to 90% of patients, but is usually mild (less than 10 times the upper limit of normal).Rhabdomyolysis is a distinctively uncommo

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